Wednesday, May 21, 2008

New SpotBot Publications

From microRNA to HTS, the SpotBot empowers researchers to develop applications that easily translate to high throughput manufacturing with our NanoPrint system. Here are some interesting and recent papers.

MicroRNA Expression Profiles in Serous Ovarian Carcinoma
EJ Nam, H Yoon, SW Kim, H Kim, YT Kim, JH Kim, JW … - Clinical Cancer Research, 2008 - AACR
This paper takes advantage of the SpotBot microarrayer and SuperEpoxy 2 Surface chemistry. The results from this study indicate that dysregulation of microRNAs is involved in ovarian carcinogenesis and associated with the prognosis of serious ovarian carcinoma. This is not the first microRNA paper where the SpotBot was used, Ambion used the SpotBot to develop their microRNA product line.

Electrical DNA-chip-based identification of different species of the genus Kitasatospora -
R Möller, T Schüler, S Günther, MR Carlsohn, T … - Applied Microbiology and Biotechnology, 2008 - Springer
In this paper, the authors describe how to use DNA microarrays for the identification of different Kitasatospora straints. The microarrays made with the SpotBot were used in conjunction with a unique electrical detection scheme. SpotBot's are also used with Biacore FlexChip SPR detection, our SpotWare Colorimetric scanner and many other types of detection systems.

A novel immobilization strategy using oligonucleotide as linker for small molecule microarrays …
P Zuo, BC Ye - Biosensors and Bioelectronics, 2008 - Elsevier
In this paper the authors use the SpotBot to test out a new surface chemistry for the manufacturing of small molecule microarrays. The getting HTS applications out of 384 and 1536 well plates will dramatically reduce the cost of HTS.