Wednesday, November 25, 2009

Companion Diagnostics

Companion Diagnostic genetic tests where a single assay is used to test each patient or sample is too expensive to become of practical use for real world diagnostics applications. Our miniaturized and patented method utilizes our ex-situ microarray platform to enable the affordable screening of tens to tens of thousands of different patients or samples for many genetic variations in a single assay. This method dramatically increases throughput and hence makes genetic screening more afforable than sequencing, real time PCR, oligonucleotide microarrays, beadarrays and other methods.

Variation Identification Platform™. Our methods provide universal microarray-based platform for genetic screening. In one embodiment, specific chromosomal loci are amplified by use of the polymerase chain reaction (PCR), printed into microarrays, and hybridized with fluorescent oligonucleotides. The fluorescent microarrays are then scanned for specific fluorescence emission and signal strengths provide genotyping information. The ability to genotype a high number of patient samples is physically impossible to perform with competing platforms.

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